To get things up and running, you would just need to first connect the included USB cable from your computer's USB port to the D1; then you'll need to connect the RCA outputs to your powered speakers/ AV receiver or your headphones to the headphone output on the front of the D1. 


Next, if using a Mac, you will need to go to System Preferences/Sound, and select "Audioengine D1"; if you're using a PC, no setting changes are needed as the computer will automatically find the USB driver. Finally, you'll just need to play music from iTunes or your favorite media player and that's it! Setup really is that easy!